Organ ATTACK! blends medically accurate terminology with immature potty humour.

In the game, each player is dealt a set of organs. The players use immunity, affliction, and other tactical cards to protect themselves while inflicting disease & bodily harm on their opponents.The last person with at least one organ remaining wins.

The object of the game is to remove your opponents' organs using corresponding afflictions before they remove yours. The last person to still have at least one organ is the winner.